The film revolves around Royce (Adrien Brody), a mercenary who reluctantly leads a group of elite warriors who come to realize they've been brought together on an alien planet... as prey. With the notable exception of a disgraced physician, they are all cold-blooded killers - mercenaries, Yakuza, convicts, death squad members - human "predators" that are now being systemically hunted and eliminated by a new breed of alien Predators.