Years after the Raccoon City disaster, Alice (MILLA JOVOVICH) is on her own knowing that she has become a liability and could endanger those around her is struggling to survive and bring down the Umbrella Corporation lead by the sinister Albert Wesker (JASON O'MARA) and head researcher Dr. Issacs (IAN GLEN). Meanwhile traveling through the Nevada Desert and through the ruins of Las Vegas Carlos Olivera, (ODED FEHR) L.J., (MIKE EPPS) and new survivors K-Mart, (SPENCER LOCKE) Claire Redfield,(ALI LARTER) and Nurse Betty (ASHANTI) must fight to survive extinction against hoards of zombies, killer crows and the most terrifying creatures created as a result of the deadly T-Virus that has killed millions.